Prerequisite: 18:363.

This course will examine in detail the molecular mechanisms by which therapeutics affect neuronal function. The course will focus on pharmacological agents that act on enzymes and neurotransmitter receptors within the central nervous system. The course will start with a review of the major neurotransmitter systems in the central nervous system, focusing on the major neural projection pathways and the synthesis and degradation of neurotransmitters. The effects of pharmacotherapies for major central nervous systems disorders including schizophrenia, affective (mood) disorder, epilepsy, Parkinson’s disease and Alzheimer’s disease will be examined. The molecular basis of action of gaseous and injection anesthetic agents will also be examined. The course will finish with an examination of the neural basis of drug abuse and addiction and its pharmacotherapy.

Cross-registered with (Chemistry) 18:453.

3 lecture hours per week, one term.