15:458 Genotoxicology [Majumder]

Prerequisite: 15:282.

This course will familiarize students with the basic principles of genotoxicity, DNA damage due to toxic chemicals, pollutants, pesticides, herbicides and carcinogens, and pathological problems due to environmental toxicity. This course will emphasize the current molecular understanding of complex and chronic disease development in humans and on how such understanding influences diagnosis, treatment, and prevention strategies. Some of the concepts addressed include characterization of relevant genotoxic agents in Manitoba, toxicants mode of action, cellular signaling pathways that control the development of diseases, the importance of genomic stability in chronic and complex diseases, mechanisms and practical approaches to prevent diseases, identification of novel targets for rational drug design, and the importance of systems approaches (e.g., genomics, proteomics) in the study of genotoxicity.

3 lecture hours per week, one term.

Instructor: Mousumi Majumder