15:470 Genomics and Bioinformatics [LeMoine/Melvin]

Prerequisite: 15:282.

Bioinformatics is an interdisciplinary field of biology that combines the use of computer science and statistics to process genome data. Genomics is the analysis of the structures and functions of entire genomes. This course will teach students how to generate biological databases from sequenced genomes and then use bioinformatics to solve problems arising from the genome data. The course will emphasize human, Neanderthal and chimpanzee genomes and through comparative analyses will attempt to answer the question “What makes us human”? The principles of organization, retrieval, manipulation and analysis of sequence data will be used to examine chromosomes, genomic organization and genetic and physical mapping of the genomes. Data generated will be used to address problems in genome epidemiology, genetic variation in specific diseases (e.g. cancer, diabetes), genome-wide association studies, complex gene-environment and gene-gene interactions and the human spectrum.

3 laboratory tutorial hours per week, one term.